The accumulation of lingering senescent cells in all tissues is one of the causes of aging. Even in very late life, senescent cells are thought to account for only a few percent at most of all cells in any given tissue, but they cause great disruption to tissue structure and function: chronic inflammation, impaired regeneration, fibrosis, and other unpleasant outcomes. This is accomplished via an as yet incompletely cataloged mix of secreted molecules known as the senescence-associated secretory phenotype, or SASP. Acting via secretions allows a small number of cells to have large effects. When present for a limited period of time, senescent cells are helpful, a necessary part of wound healing, embryonic development, and suppression of cancer. Cells become senescent in response to the circumstance
from https://aubreyflores.blogspot.com/2019/06/understanding-why-immune-system-fails.html
from
https://aubreyflores1.tumblr.com/post/185557931044
From https://tommysmith1.blogspot.com/2019/06/understanding-why-immune-system-fails.html
from
https://tommysmith1.wordpress.com/2019/06/13/understanding-why-the-immune-system-fails-to-destroy-lingering-senescent-cells-may-lead-to-new-senolytic-therapies/
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